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KMID : 1005220090240030189
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Journal of Embryo Transfer
2009 Volume.24 No. 3 p.189 ~ p.197
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Two-Pore Domain Channels Expressed in Mammalian Reproductive Cells and Organs
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Lee Hyo-Zhin
Han Jae-Hee
Kang Da-Won
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Abstract
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Two-pore domain channels contribute to setting the resting membrane potential in excitable and nonexcitable cells. However, the cellular or tissue distribution and function of channels expressed in mammalian germ cells and reproductive organs have not yet been reviewed by researchers. In this review, we focus on expression, localization and expected properties of channels in germ cells and reproductive organs. The channels are expressed in human cytotrophoblast cells, myometrium, placental vascular system, uterine smooth muscle, and pregnant term tissue, suggesting that channels might be involved in the processes of pregnance. The channels are also expressed in mouse zygotes, monkey sperm, ovary, testis, germ cells, and embryos of Korean cattle. Interestingly, channels are modulated by changes in temperature and oxygen concentration which play an important role in embryonic development. Also, channels are responsible for efflux during apoptotic volume decreases in mouse zygotes. These expression patterns and properties of the channels in reproductive organs and germ cells are likely to help the understanding of ion channel-related function in reproductive physiology.
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KEYWORD
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two-pore domain K+ channel, germ cell, reproductive organ, ion channel
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